A recent study has established a connection between antidepressant use and a lower prevalence of periodontitis, a serious gum disease. The findings were published online on October 29, 2025, in the Journal of Periodontology. Researchers from the University Complutense in Madrid, led by María Martínez, analyzed data from 9,839 participants in the U.S. National Health and Nutrition Examination Survey, conducted from 2009 to 2014.
The study revealed that the overall prevalence of periodontitis was 35.3% for moderate cases and 11.1% for severe ones. Notably, the use of antidepressants was associated with a significant reduction in the odds of developing periodontitis across various classifications. The association was particularly pronounced for severe cases, with an adjusted odds ratio of 0.68 for advanced periodontitis (stages III to IV) and an odds ratio of 0.41 for severe periodontitis.
Insights from the Research
The research highlights the complex relationship between mental health and oral health. Ana Becil Giglio, president of the American Academy of Periodontology, commented on the findings, stating, “We have known for a long time that depression and gum disease can influence each other. This study adds an intriguing new layer, suggesting that antidepressant use may help protect against severe forms of periodontal disease.”
The implications of this research are significant, as periodontitis can lead to tooth loss and has been linked to other health issues, including cardiovascular disease and diabetes. The study underscores the importance of addressing mental health not only for emotional well-being but also as a potential factor in maintaining oral health.
Future Directions
As the research community continues to explore the connections between mental health and physical health, further studies will be essential to understand the mechanisms behind this association. The findings may also encourage healthcare professionals to consider the broader implications of antidepressant prescriptions, particularly in relation to oral health outcomes.
This study serves as a reminder of the interconnected nature of health, urging a comprehensive approach to treatment that encompasses both mental and dental care. As more data emerges, it may pave the way for new preventative strategies and treatment options for individuals at risk of periodontitis.
For additional information, refer to the full study by María Martínez et al., titled “Reduced prevalence of periodontitis in antidepressant users: Findings from a large‐scale US sample,” in the Journal of Periodontology.
